An antiestrogen-binding protein in human tissues.

Expression and Distribution of Calcium-Binding Protein S100P in Human Placenta during Pregnancy

Characterization and Quantitation of Antiestrogen Binding Sites in Estrogen Receptor-positive and -negative Human Breast Cancer

Antiestrogens are useful in the treatment of endocrine-respon sive breast cancers in humans. In an attempt to understand the mechanisms underlying their estrogen antagonism and antitumor character, we have examined the interaction of antiestrogens with three human breast cancer cell lines that differ markedly in their estrogen receptor content and in their sensitivity to growth suppression by a...

Increased expression of heat shock protein-binding protein 1 and heat shock protein 70 in human hepatocellular carcinoma tissues.

Heat shock protein-binding protein 1 (HspBP1) is a co-chaperone that inhibits heat shock 70-kDa protein (Hsp70) activity. In mouse neuroblastomas and lung tumors, the protein levels of HspBP1 and Hsp70 are elevated by a similar amount compared to non-tumor tissues. However, no studies have been reported regarding the levels of HspBP1 in human cancer tissues. Our previous proteomic study demonst...

P 200 immunohistochemical distribution of FK506 binding protein in human ocular tissues

Purpose To investigate the peripheral blood T-cell subpopula-tions in patients with different forms of uveitis. Met/rods The CD 3+, CD 4+ and CD 8+ lymphocyte subsets were studied in peripheral blood by flowcflomeby in 220 patients with anterior, intermediate, posterior and panuveitis (150 cases with proven etiology and underlined clinical syndrome and 70 with idiopathic uveitis). The control g...

The calcium-binding protein S100P in normal and malignant human tissues

BACKGROUND S100P is a Ca2+ binding protein overexpressed in a variety of cancers, and thus, has been considered a potential tumor biomarker. Very little has been studied about its normal expression and functions. METHODS We examined S100P expression in normal human tissues by quantitative reverse transcription polymerase chain reaction and immunohistochemistry. S100P protein expression was al...